Welcome to The Briercliffe Society Forum

The forum is free to join and you do not need to be a member of the society. You will receive an email to activate your account before you will be able to log in. Please check spam filters and junk mail folders for this email.
It is currently Mon Oct 23, 2017 2:40 pm

All times are UTC [ DST ]




Post new topic Reply to topic  [ 71 posts ]  Go to page 1, 2, 3, 4, 5  Next
Author Message
 Post subject: DNA testing
PostPosted: Tue Oct 09, 2007 6:06 pm 
Computer Whizz
User avatar

Joined: Fri Mar 02, 2007 9:28 am
Posts: 3879
Location: Near Chorley
Has anyone had their DNA done?

_________________
Gloria

I'd be dangerous with a brain.


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Wed Oct 10, 2007 8:31 am 
Spider Lady
User avatar

Joined: Thu Mar 01, 2007 9:23 pm
Posts: 8051
Location: Staffordshire
I know Kris has but I'm not sure what his results came out as. He did send me a copy of the report but it meant nothing to me...he was thinking of taking it further. He's back off his hols at the end of this week so hopefully he will fill you in on it then.
I think it cost about £100

_________________
Mel

Searching for lost relatives? Win the Lottery!


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Mon Oct 15, 2007 1:54 pm 
Computer Whizz
User avatar

Joined: Fri Mar 02, 2007 9:28 am
Posts: 3879
Location: Near Chorley
Kris, exactly what do you find out? I once got told it could just say european!!!! I would have thought americans would find it very interesting.

_________________
Gloria

I'd be dangerous with a brain.


Top
 Profile  
Reply with quote  
 Post subject: DNA Test
PostPosted: Mon Oct 15, 2007 10:43 pm 
Willfinder General
User avatar

Joined: Mon Mar 19, 2007 4:51 pm
Posts: 3007
Location: Vancouver Island, Canada
Hi Gloria, I did a 12 Y- DNA marker test with the National Geographic which basically showed the Human Migration root my forefathers travelled from Africa to Northern Europe over the last 50,000 years. When I received my results I posted my 12 markers to various internet groups of people that also share these same markers. This basically says we come from the same genetic father line.

From here I can take further DNA tests, 25, 37 or 67 marker tests on my Y chromosome (fathers line). I plan on doing this soon as all these tests are in US $ and the £ is very strong at the moment. You need to do at least 37 markers to determine if you share a recent ancestor (within a couple of hundred years).

There is more on this topic here - http://www.familytreedna.com/genbygenad.html and here http://www.dnaandfamilyhistory.com/gene ... ects.shtml

DNA testing is not for everyone, but I find the genetics aspect fascinating!! Check this out, it is kind of off topic but… - http://www.healthline.com/galecontent/c ... ysplasia-1



Cleidocranial dysplasia
Definition
Cleidocranial dysplasia (CCD), also known as cleidocranial dysostosis, is a hereditary condition characterized by abnormal clavicles, delayed fusion of the bones in the skull, extra teeth, short stature, and other skeletal changes.
Description
Cleidocranial dysplasia is one of the skeletal dysplasia conditions, a large family of disorders involving abnormal growth and development of the skeleton.
CCD involves a characteristic group of abnormalities affecting primarily the skull, teeth, and clavicles. Other bones, such as the ribs, pelvis, and bones of the hands and feet may also be affected. Older children and adults with CCD are typically shorter than average. Most individuals with this condition do not have significant physical or mental disability.
Genetic profile
CCD is an autosomal dominant condition with variable expressivity (variable symptoms) and complete penetrance (meaning that all individuals who carry the gene for CCD have some symptoms). It is estimated that one third of cases represent new mutations, or genetic changes. The gene responsible for CCD has been mapped to the short arm of chromosome 6 and is called CBFA1. This gene encodes a transcription factor, meaning a protein that regulates DNA transcription, and is specifically expressed in the bone. Mutations in CBFA1 have been identified in many individuals and families with CCD.
Demographics
More than 500 cases of CCD among individuals of various ethnic backgrounds have been described in the medical literature. The incidence of CCD is reported to be highest around Cape Town, South Africa. The number of affected individuals in this area was estimated to exceed 1,000 as of 1996. These individuals descended from an affected Chinese sailor who settled in the area in 1896 and had seven wives. Study of this large family helped localize the gene responsible for the condition.
Signs and symptoms

Individuals with CCD typically show a delay or failure of the fusion of the calvarial sutures, the openings between the bones of the skull in infants. In some cases, the anterior fontanelle (the "soft spot" on an infant's head) or other areas of the skull may remain unfused through life. A typical facial appearance in persons with CCD includes a broad forehead and widely spaced eyes. The overall head size is usually at the upper limit of normal.
Almost all persons with CCD have some degree of hypoplasia, or underdevelopment, of the clavicles (collar bones). In severe cases, both clavicles may be absent. More commonly, there is hypoplasia of the outside end of the clavicles. Depending on the degree of severity of clavicular hypoplasia, the external appearance of the shoulder may be affected. Some persons with CCD appear to have narrow, sloping shoulders, and some have the unusual ability to bring their shoulders together beneath their chin. This defect usually does not result in physical disability for the individual.
Dental abnormalities are very frequent among persons with CCD and are considered characteristic of the disorder. Almost all individuals are slow to lose their deciduous teeth (baby teeth), with a delay in the eruption of the permanent teeth. Some persons with CCD describe "living without teeth" until their permanent teeth started growing. Additionally, there may be a large number of extra teeth present. These extra teeth are so numerous so as to constitute a more or less complete third set of teeth. Additionally, the enamel of the teeth may be abnormal and prone to decay.
Other signs of CCD include a small rib cage with short or abnormal ribs. The vertebra of the spine may be malformed. The pelvis may be underdeveloped, with an increased space between the pubic bones. The growth of the bones in the hands and feet are often abnormal; most are shorter but others are longer than normal. Final height in adults with CCD is usually shorter than expected given the family background.
More unusual complications associated with CCD include scoliosis (curvature of the spine), bone fragility, deafness, cleft palate, and a small jaw.
Diagnosis
The diagnosis of CCD is typically made by the doctor following review of the information obtained from physical exams, history, and x ray or other studies. The clavicular hypoplasia may only be seen on x rays.
The combination of hypoplastic clavicles, open fontanelles, and extra teeth is considered typical of CCD. The multiple dental anomalies in CCD are also quite specific and the diagnosis is evident in any individual with normal deciduous teeth, delayed eruption of permanent teeth, and multiple extra teeth.
Testing of the CBFA1 gene for mutations may also be performed. Identification of a mutation may confirm the initial diagnosis, or allow diagnosis before birth.
In a few cases, recognition of the features of CCD by ultrasound imaging, a technique that produces pictures of the fetus, has led to diagnosis of the condition before birth.
Treatment and management
There is no specific treatment for cleidocranial dysplasia. Typically, a course of treatment is designed to manage the specific symptoms.
Children with CCD may be screened for deafness.
Long term dental treatment is often required. Surgery may be performed to remove the baby teeth and open the bony coverings surrounding the permanent teeth, with the goal of promoting their eruption. Orthodontic procedures may be required to align the teeth.
In pregnant females with CCD, the hypoplastic pelvis often necessitates a caesarian section delivery.
Prognosis
CCD is not expected to affect life expectancy in most cases and most diagnosed persons enjoy good over-all health.
In some newborns, the small rib cage and reduced lung capacity may lead to respiratory distress. Height is often lower compared to that of other family members. The clavicular hypoplasia does not appear to significantly impair function, and some individuals with hypoplastic or absent clavicles have worked as manual laborers without difficulty. Dental problems are expected, and are sometimes severe enough so as to become a "dental disability." Intelligence is usually normal.


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Tue Oct 16, 2007 5:45 pm 
Computer Whizz
User avatar

Joined: Fri Mar 02, 2007 9:28 am
Posts: 3879
Location: Near Chorley
Fascinating article, and all from a chinese sailor with seven wives.
I have often thought about having it done, but up to now that has just been a thought.
What made you do it?

_________________
Gloria

I'd be dangerous with a brain.


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Tue Oct 16, 2007 6:16 pm 
Willfinder General
User avatar

Joined: Mon Mar 19, 2007 4:51 pm
Posts: 3007
Location: Vancouver Island, Canada
I know, how crazy is that? I watched a documentary on this a few years back and all of this mans descendents had no collar bone, a strange genetic mutation being passed down through the generations!

I worked with a woman of Irish origins and her brother did a 37 Y DNA Marker test, he came across a number of people who shared similar markers and most could trace their family roots back to Ireland. I don’t think any of these people shared the same surname, but it is interesting all the same. It would be interesting to do a DNA one name study to see if there was a connection.

Like I say, £ Sterling is strong at the moment so it’s a good time to spend them US$


Top
 Profile  
Reply with quote  
 Post subject: DNA
PostPosted: Wed Oct 17, 2007 10:02 pm 
Genealogist in Waiting
User avatar

Joined: Wed Jun 13, 2007 8:57 pm
Posts: 389
Location: Richards Landing, Ontario, Canada
This would be a fascinating seminar at the silver anniversary...at least for moi!


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Sun Oct 21, 2007 8:30 am 
Spider Lady
User avatar

Joined: Thu Mar 01, 2007 9:23 pm
Posts: 8051
Location: Staffordshire
I'll put your suggestion to Roger Sue. I think the difficulty will be finding someone locally with the knowledge.

I see Ancestry are getting involved with DNA now http://landing.ancestry.co.uk/offers/uk/dna.aspx

_________________
Mel

Searching for lost relatives? Win the Lottery!


Top
 Profile  
Reply with quote  
 Post subject: Dr. Spencer Wells
PostPosted: Sun Oct 21, 2007 1:46 pm 
Willfinder General
User avatar

Joined: Mon Mar 19, 2007 4:51 pm
Posts: 3007
Location: Vancouver Island, Canada
Hi, I should have showed you these links earlier.

Explore your own genetic journey with Dr. Spencer Wells

Journey of Man: A Genetic Odyssey (Part 1 of 13)
http://www.youtube.com/watch?v=OV6A8oGt ... ed&search=

Journey of Man: A Genetic Odyssey (Part 2 of 13)
http://www.youtube.com/watch?v=ybji0axp ... ed&search=

Journey of Man: A Genetic Odyssey (Part 3 of 13)
http://www.youtube.com/watch?v=M25Ez4HW ... ed&search=

Journey of Man: A Genetic Odyssey (Part 4 of 13)
http://www.youtube.com/watch?v=BA3aINMI ... ed&search=

Journey of Man: A Genetic Odyssey (Part 5 of 13)
http://www.youtube.com/watch?v=0m2-RwYX ... ed&search=

Journey of Man: A Genetic Odyssey (Part 6 of 13)
http://www.youtube.com/watch?v=N0QDrODn ... ed&search=

Journey of Man: A Genetic Odyssey (Part 7 of 13)
http://www.youtube.com/watch?v=EMzaQhqH ... ed&search=

Journey of Man: A Genetic Odyssey (Part 8 of 13)
http://www.youtube.com/watch?v=xhZ7zaT5 ... ed&search=

Journey of Man: A Genetic Odyssey (Part 9 of 13)
http://www.youtube.com/watch?v=QV3Ws7py ... ed&search=

Journey of Man: A Genetic Odyssey (Part 10 of 13)
http://www.youtube.com/watch?v=nNlvzhfQ ... ed&search=

Journey of Man: A Genetic Odyssey (Part 11 of 13)
http://www.youtube.com/watch?v=8KzroCQV ... ed&search=

Journey of Man: A Genetic Odyssey (Part 12 of 13)
http://www.youtube.com/watch?v=jl-bnnES ... ed&search=

Journey of Man: A Genetic Odyssey (Part 13 of 13)
http://www.youtube.com/watch?v=AT6XsVnu ... ed&search=

and

Genographic Project: Our History Within
http://www.youtube.com/watch?v=gdFB2w0LzKo

and

The Genographic Project, Part 1
http://www.youtube.com/watch?v=QmlVG_1w ... ed&search=

The Genographic Project, Part 2
http://www.youtube.com/watch?v=YYePOin8 ... e%20Canaan


this is interesting as well

Part.1 - The Genetic Impact of Empire
http://www.youtube.com/watch?v=d4V_tskDXAk

Part 2. - Tracing Genetic History (Incomplete)
http://www.youtube.com/watch?v=Z3uotXZ43MU

Part.3 - The Phoenician Imprint
http://www.youtube.com/watch?v=-ZjF5Ifu ... ed&search=

There are more DNA links on youtube.

If you are interested in doing a test, this is the link - https://www3.nationalgeographic.com/genographic/


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Sun Oct 21, 2007 5:58 pm 
Computer Whizz
User avatar

Joined: Fri Mar 02, 2007 9:28 am
Posts: 3879
Location: Near Chorley
I know someone who is willing to give a talk.

_________________
Gloria

I'd be dangerous with a brain.


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Sun Oct 21, 2007 7:07 pm 
Spider Lady
User avatar

Joined: Thu Mar 01, 2007 9:23 pm
Posts: 8051
Location: Staffordshire
Are you going to be at the meeting on the 31st Gloria? Maybe we could put the suggestion to Roger to see what he thinks. Wouldn't it be cool to get a DNA profile of those of us who have Briercliffe ancestors to see just how related we all are!
Second thoughts...thats a bit scary!

_________________
Mel

Searching for lost relatives? Win the Lottery!


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Sun Oct 21, 2007 8:31 pm 
Computer Whizz
User avatar

Joined: Fri Mar 02, 2007 9:28 am
Posts: 3879
Location: Near Chorley
Yes I am hoping to be there.
As regards the DNA, the contact is a mine of info on it. We have just had a very interesting chat over a bottle of wine.

_________________
Gloria

I'd be dangerous with a brain.


Top
 Profile  
Reply with quote  
 Post subject: Re: DNA
PostPosted: Sun Oct 28, 2007 5:10 pm 
Spider Lady
User avatar

Joined: Thu Mar 01, 2007 9:23 pm
Posts: 8051
Location: Staffordshire
suzycue44 wrote:
This would be a fascinating seminar at the silver anniversary...at least for moi!

Mentioned this to Roger, We've to bring it up at the meeting on Wednesday. Will keep you informed when any plans are released.

_________________
Mel

Searching for lost relatives? Win the Lottery!


Top
 Profile  
Reply with quote  
 Post subject:
PostPosted: Thu Nov 29, 2007 10:19 pm 
Spider Lady
User avatar

Joined: Thu Mar 01, 2007 9:23 pm
Posts: 8051
Location: Staffordshire
If I were to go down this DNA route...I want to get as much as possible for my money. I'm not 100% convinced about DNA genealogy.

If I ordered a test kit, is it a swab or a blood test?
Would I be able to use it on my nephew rather than myself? He's 8 or 9.

The reason I am thinking of using my nephew is because his mum is my sister and his dad is Lyndons brother. Would the results just show his paternal result or would I get a maternal result too?

I'm wondering if could get DNA data for both Lyndons family and mine in one hit!

_________________
Mel

Searching for lost relatives? Win the Lottery!


Top
 Profile  
Reply with quote  
 Post subject: Re: Dr. Spencer Wells
PostPosted: Thu Nov 29, 2007 11:10 pm 
Willfinder General
User avatar

Joined: Mon Mar 19, 2007 4:51 pm
Posts: 3007
Location: Vancouver Island, Canada
Leaver wrote:
Journey of Man: A Genetic Odyssey (Part 1 of 13)
http://www.youtube.com/watch?v=OV6A8oGt ... ed&search=

Journey of Man: A Genetic Odyssey (Part 2 of 13)
http://www.youtube.com/watch?v=ybji0axp ... ed&search=

Journey of Man: A Genetic Odyssey (Part 3 of 13)
http://www.youtube.com/watch?v=M25Ez4HW ... ed&search=

Journey of Man: A Genetic Odyssey (Part 4 of 13)
http://www.youtube.com/watch?v=BA3aINMI ... ed&search=

Journey of Man: A Genetic Odyssey (Part 5 of 13)
http://www.youtube.com/watch?v=0m2-RwYX ... ed&search=

Journey of Man: A Genetic Odyssey (Part 6 of 13)
http://www.youtube.com/watch?v=N0QDrODn ... ed&search=

Journey of Man: A Genetic Odyssey (Part 7 of 13)
http://www.youtube.com/watch?v=EMzaQhqH ... ed&search=

Journey of Man: A Genetic Odyssey (Part 8 of 13)
http://www.youtube.com/watch?v=xhZ7zaT5 ... ed&search=

Journey of Man: A Genetic Odyssey (Part 9 of 13)
http://www.youtube.com/watch?v=QV3Ws7py ... ed&search=

Journey of Man: A Genetic Odyssey (Part 10 of 13)
http://www.youtube.com/watch?v=nNlvzhfQ ... ed&search=

Journey of Man: A Genetic Odyssey (Part 11 of 13)
http://www.youtube.com/watch?v=8KzroCQV ... ed&search=

Journey of Man: A Genetic Odyssey (Part 12 of 13)
http://www.youtube.com/watch?v=jl-bnnES ... ed&search=

Journey of Man: A Genetic Odyssey (Part 13 of 13)
http://www.youtube.com/watch?v=AT6XsVnu ... ed&search=



It’s a cheek swab, and your nephew could do either a paternal or maternal line but you would need two kits if you want both results.

The Journey of Man videos above will give you a good idea of what to expect. These videos are so interesting!!!! :D


Top
 Profile  
Reply with quote  
Display posts from previous:  Sort by  
Post new topic Reply to topic  [ 71 posts ]  Go to page 1, 2, 3, 4, 5  Next

All times are UTC [ DST ]


Who is online

Users browsing this forum: No registered users and 0 guests


You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot post attachments in this forum

Search for:
Jump to:  
cron
Powered by phpBB® Forum Software © phpBB Group